FPR1 might play a relevant role in prevention of liver fibrosis

Introduction: Formylpeptide receptors (FPR) are mainly studied as chemotactic receptors during sterile and pathogen associated inflammation. They are expressed on immune cells but also non-hematopoietic tissues. Theirs ligand fMLF is represented on bacteria or is secreted by mitochondria after apoptosis. Together they can induce a strong chemotactic movement. The role of FPRs in during hepatitis and liver fibrosis is so far poorly understood. Besides, immunoregulation and maintainance of immunehomeostasis is important to prevent hepatitis and to avoid the establishment of liver fibrosis. Material and Methods: We…