Functional role of CCL5/RANTES for HCC progression during chronic liver disease: from humans to mice
A Mohs, N Kuttkat, J Reißing, HW Zimmermann, A Proudfoot, SA Youssef, A de Bruin, FJ Cubero, C Trautwein · Zeitschrift für Gastroenterologie · 2015 · Heft 12
Bibliografische Angaben
Zusammenfassung
Background & Aims: Hepatocellular carcinoma (HCC) which is the consequence of malignant transformation of hepatocytes, is often based on chronic inflammation, resulting in liver fibrogenesis. During this process chemokines play a crucial role by attracting immune cells. In the current study, the function of CCL5/RANTES during chronic liver disease (CLD) was analysed in patients and two independent murine models of inflammation triggered HCC development. We showed that CCL5 acts mainly through immune cells by influencing the pro-inflammatory milieu in the diseased liver. Finally, we present an efficient therapeut…
