Deregulation of the Hippo/YAP pathway drives chromosomal instability (CIN) in hepatocellular carcinoma by regulating the transcription factor FoxM1
S Weiler, F Pinna, T Lutz, T Wolf, S Roessler, S Wan, S Singer, M Knaub, J Marquardt, H Lang, JS Lee, P Schirmacher, V Kalinichenko, K Breuhahn · Zeitschrift für Gastroenterologie · 2015 · Heft 12
Bibliografische Angaben
Zusammenfassung
The Hippo/YAP signaling pathway is an important regulator of cell proliferation and organ growth. YAP has been described as an oncogene, promoting hepatomegaly and the formation of hepatocellular carcinoma (HCC) (Zender et al. 2006). However, the precise downstream mechanisms of YAP-dependent tumorigenesis are only poorly understood. In this study we examined the role of YAP in the regulation of chromosomal instability (CIN) in hepatocarcinogenesis. Using siRNA treatments and Luciferase assays we showed that YAP regulates the transcription factor FoxM1 on a transcriptional level in different HCC cell lines. More…
