Mechanistic dynamics of Hepatitis C virus replication in single liver cells
MM Knodel, A Nägel, S Reiter, M Rupp, A Vogel, P Targett-Adams, J McLauchlan, E Herrmann, G Wittum · Zeitschrift für Gastroenterologie · 2015 · Heft 12
Bibliografische Angaben
Zusammenfassung
Infection with hepatitis C virus (HCV) causes chronic liver diseases. Strong biological evidence suggests intracellular spatial dependence is a crucial factor in the process the virus uses to replicate its RNA genome. For HCV, replication is believed to occur in specialized compartments within virus-infected cells, termed replication complexes. Replication complexes are derived from altered regions of an interconnected intracellular membrane network called the Endoplasmic Reticulum (ER). The HCV-encoded NS5A protein is an essential component of HCV replication and probably contributes many functions that the vir…
