The fixed-dose combination of tiotropium + olodaterol has a rapid onset of action in patients with COPD

Background: Tiotropium (T) is an established once-daily long-acting muscarinic antagonist that improves the main functional and patient-orientated outcomes of COPD. The long-acting ß2-agonist olodaterol (O) has a rapid onset of action (5 mins post-dose) providing 24-h bronchodilation in patients with COPD.1 The TONADO studies investigated the efficacy and safety of the fixed-dose combination (FDC) of T and O over 1 year in moderate to very severe COPD.2 This analysis determined the onset of bronchodilation after first administration. Methods: Two 52-week, double-blind, parallel-group studies were conducted. Pati…