Impact of the GTPase ARFRP1 on chylomicron maturation

Background: Abnormalities in lipid metabolism and lipoprotein and lipid droplet (LD) formation can lead to dyslipidaemia, fatty liver disease and type 2 diabetes. Lipoprotein and LD synthesis are initiated in the ER, further maturation occurs in the Golgi apparatus. We have recently shown that deletion of GTPase ARFRP1 in the intestinal epithelium results in impaired chylomicron (CM) formation. ARFRP1 recruits ARL1 and Golgins, that interact with several Rab GTPases to the trans-Golgi and is thereby involved in cellular trafficking events. The aim was to clarify the mechanisms involved in the lipidation and rele…