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Influence of the genetic background on the diabetic phenotype and postnatal development of the endocrine pancreas of GIPRdn transgenic mice

N Herbach, JSA Röder, A Blutke, R Wanke · Diabetologie und Stoffwechsel · 2016 · Heft 04

Dokument
878870
CareLit-ID
Jahr
2016
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
N Herbach, JSA Röder, A Blutke, R Wanke
Ausgabe
Heft 04 / 2016
Seiten
–
Erschienen: 2016-04-19 00:00:00
ISSN
1861-9002
DOI
10.1055/s-0036-1580891

Zusammenfassung

Aims: GIPRdn transgenic mice on the CD1 outbred genetic background show loss of functional beta cell mass in combination with a severe diabetic phenotype. In this study, the influence of the genetic background FVB/N (F.CD1-GIPR dn) and C57Bl/6J (B6.CD1-GIPR dn) on the diabetic phenotype and the postnatal development of the endocrine pancreas of GIPRdn transgenic mice were investigated. Methods: GIPRdn transgenic mice were back crossed to FVB/N and C57Bl/6 genetic background for over ten generations. In vivo tests concerning glucose homeostasis and quantitative stereological analyses of the endocrine pancreas wer…

Schlagworte

Diabetologie und Stoffwechsel