Impact of mulberry leaf extract and mulberry leaf powder on serum nesfatin-1 level in nicotinamide/streptozotocin-induced type 2 diabetic rats

Introduction: The white mulberry leaves (Morus Alba L.) are used in traditional medicine as anti-diabetics, because it contains flavonoids, can act as insulin secretagogues or insulin mimetics. Nesfatin-1 is a novel anorexigenic regulatory peptide and affects glucose metabolism by increasing insulin sensitivity. We investigated the effect of Mulberry leaf extract (MLE) and Mulberry leaf powder (MLP) on Nesfatin-1; fasting blood glucose (FBG) and insulin levels in streptozotocin-nicotinamide (STZ-NA) induced type 2 diabetes. Materials and methods: 30 male wistar rats were divided randomly into five groups. One of…