Chamomile flower, myrrh and coffee charcoal, components of a traditional herbal medicinal product, diminish pro-inflammatory activation in human macrophages

Background: The traditional herbal medicinal product Myrrhinil-Intest®, a combination of myrrh, chamomile flower and coffee charcoal is used for the relief of gastrointestinal complaints. Clinical studies suggest its use in the maintenance therapy of inflammatory bowel disease [1]. However, the pharmacological mechanisms underlying the clinical effects are not yet fully understood. Aim: The present study aims to elucidate immunopharmacological activities of myrrh, chamomile flower and coffee charcoal by studying their influence on gene expression and protein release of activated human macrophages. Methods: The e…