Prioritizing drug targets for non-alcoholic fatty liver disease based on comorbidity network analysis

Background and aims: Non alcoholic fatty liver disease (NAFLD) is highly associated with other components of the metabolic syndrome, in particular obesity and diabetes. However, systematic network medicine approach of the complex phenotypic dependencies and comorbidities has yet to be performed. Our aim now is to identify novel drug targets for NAFLD treatment by a systematic in silico network analysis. Methods: We constructed an interaction network of curated genes relevant to NAFLD and its comorbid diseases of interest. Network mining was applied to characterize the NAFLD comorbidity network, and identify the…