CD26/DPP4-inhibition suppresses lung cancer growth via increased NK cell and macrophage recruitment

Hintergrund: Lung cancer is nowadays the main cause of death among all cancers. CD26/DPP4 (dipeptidyl peptidase 4) is a transmembrane glycoprotein, that is constitutively expressed on hematopoetic cells, but also found on lung epithelial and endothelial cells. Previously, we found that the activity of CD26/DPP4 of lung cancer patients is four times higher than normal tissue. Here, we tested if CD26/DPP4-inhibition regulates lung cancer growth in mice. Material und Methode: An orthotopic tumor model was employed by sc. injections of the mouse lung cancer (Lewis Lung Carcinoma (LLC)) and a human lung adenocarcinom…