5DCNS+ approach for (semi-)automized evaluation of fetal cranial structures – a step toward to improve detection of CNS anomalies?

Objective: To scrutinize the performance and reliability of the 5DCNS+™ algorithm for standardized assessment of the fetal cranial structures in 2nd and 3rd trimester fetuses. Methods: In this prospective study we enrolled 440 uncomplicated singleton pregnancies undergoing targeted second and third trimester ultrasound examination at a tertiary referral center. All volume data sets were obtained with the fetus' head in an appropriate position (transverse plane, horizontal falx cerebri), absent or minimal fetal breathing/movement and satisfying image quality. After application of the 5DCNS+ software all images we…