TAp73 is a central transcriptional regulator of airway multiciliogenesis and protects bronchial function
A Nemajerova, D Kramer, S Siller, C Herr, O Shomroni, T Pena, C Gallinas Suazo, K Glaser, M Wildung, H Steffen, A Sriraman, F Oberle, M Wienken, M Hennion, R Vidal, B Royen, M Alevra, D Schild, R Bals, J Dönitz, D Riedel, S Bonn, KI Takemaru, U Moll, M Lizé · Pneumologie · 2016 · Heft 10
Bibliografische Angaben
Zusammenfassung
Motile multiciliated cells (MCCs) have critical roles in respiratory health and disease and are essential for cleaning inhaled pollutants and pathogens from airways. Mucociliary clearance defects can lead to chronic lung diseases such as bronchiectasis, Chronic Obstructive Pulmonary Disease (COPD) or Primary Ciliary Dyskinesia (PCD). Despite their significance for human disease, the transcriptional control that governs multiciliogenesis remains poorly understood. Here we identify p73, a tumor suppressive p53 homolog whose transcriptionally active form is named TAp73, as governing the program for airway multicili…
