Serum concentrations of soluble B7-H4 in early pregnancy are elevated in women with preterm premature rupture of membranes
P Mach, A Köninger, L Wicherek, R Kimmig, S Kasimir-Bauer, C Birdir, B Schmidt, A Gellhaus · Geburtshilfe und Frauenheilkunde · 2016 · Heft 10
Bibliografische Angaben
Zusammenfassung
Aim of the study: An adequate immune tolerance plays a key role in successful pregnancy. B7-H4 are co-stimulatory molecules, responsible for the negative regulation of T-cell-mediated immune responses. We analyzed soluble B7-H4 (sB7-H4) serum levels and its association with (preterm) premature rupture of membranes (pPROM). Method of study: Maternal sB7-H4 were determined with ELISA (BIOZOL, Eching, Germany) in 66 patients between 11 – 13 weeks' gestation who developed pPROM < 370/7 weeks' gestation (n = 21), PROM at term (n = 18) and in control group (n = 27). Results: Substantially higher sB7-H4 blood serum con…
