Radiosensitizing effect of 5-aza-2'-deoxycytidin in human glioblastoma cells

Glioblastoma multiforme represents the most aggressive brain tumor. Its high infiltration rate and resistance to current treatment protocols results in a median survival of only 15 months following surgical removal and standard therapy. Epigenetic modulators have been shown to inhibit the growth of IDH-mutant glioma cells and may modulate DNA repair. Here, we analyzed the combined effect of the methyltransferase inhibitor 5-aza-2'-deoxycytidine (5-aza-dC) and ionizing radiation (IR) on the clonogenic survival of human glioblastoma cells. After treatment of human T98G cells (IDH-wild-type, p53-mutated) with singl…