CareLit Fachartikel

mRNA Expression of the Androgen Receptor Gene in Cases with Intersex

H. Shima, E. Okamoto, H. Yabumoto, F. Ikoma, Y. Yamamoto · Aktuelle Urologie · 1996 · Heft S 1 · S. 49-50

Dokument
900134
CareLit-ID
Jahr
1996
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Aktuelle Urologie
Autor:innen
H. Shima, E. Okamoto, H. Yabumoto, F. Ikoma, Y. Yamamoto
Ausgabe
Heft S 1 / 1996
Jahrgang 27
Seiten
49-50
Erschienen: 1996-04-01 00:00:00
ISSN
0001-7868
DOI
10.1055/s-2008-1055652

Zusammenfassung

Summary: Normal androgen activity through the DHT-AR complex is critical in the developmental procedure of sexual differentiation in the male embryo. Impaired androgen action during this critical period caused by abnormal AR, such as thermolabile AR, might explain ambiguous genitalia, in some cases with intersex. The weak AR mRNA expressions in cases with TI, and XX male with hypospadias suggest that there might be some regulational disorders at the level of message from the AR gene behind these phenotypes.

Schlagworte

mRNA Androgen receptor Intersex Androgen Cases Critical Might Summary Normal Activity Through Dht-Ar Complex Developmental Aktuelle Urologie