L-NAME- and U 46619-induced contractions in isolated porcine ciliary arteries versus vortex veins
Niccolò Pellanda, Josef Flammer, Ivan O. Haefliger · Klinische Monatsblätter für Augenheilkunde · 2001 · Heft 05 · S. 366-369
Bibliografische Angaben
Zusammenfassung
Abstract PURPOSE To investigate contractions evoked by the thromboxane A2 analog U 46619 and by the inhibitor of nitric oxide formation NG-nitro-L-arginine methyl ester (L-NAME) in isolated porcine ciliary arteries and vortex veins. MATERIAL AND METHODS In a myograph system (for isometric forces measurement), vessels were exposed (at different levels of wall tension) to 100 mM potassium chloride (KCl). At their optimal tension, vessels were exposed (in a cumulative manner) to increasing concentrations of U 46619 (0.1 nM - 1 μM) in the absence or in the presence of L-NAME (0.1 mM). Contractions were expressed in…