CareLit Fachartikel
Serum Progranulin Levels and Disease Activity in Patients with Axial Spondyloarthritis
Irem Mercan, Pelin Oktayoglu, Nuriye Mete, Mehmet Caglayan · Aktuelle Rheumatologie · 2024 · Heft 03 · S. 191-196
Dokument
907044
CareLit-ID
Jahr
2024
Publikation
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Metadaten
DOI
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Zusammenfassung
Abstract Background Axial spondyloarthritides (ax-SpA) are a group of chronic systemic diseases of unknown aetiology, affecting mostly young men, with common features such as inflammatory low back pain, axial skeletal involvement, sacroiliitis, and association with HLA-B27. Inflammatory cytokines, mainly TNF-α, play a role in its aetiopathogenesis. Progranulin (PGRN) is thought to be an anti-inflammatory molecule that acts through the TNF-α pathway. In our study, we aimed to investigate the relationship between serum PGRN levels and disease activity in patients with AS. Material and Methods Forty-five patients b…
Schlagworte
axialspondyloarthritis
progranulin
disease activity
axiale Spondyloarthritis
Krankheitsaktivität
Aktuelle Rheumatologie
