CareLit Fachartikel
Heme oxygenase-1 is induced in endothelial cells of newly formed vessels in chronically damaged rat livers
K Tron, K Neubauer, G Ramadori · Zeitschrift für Gastroenterologie · 2004 · Heft 02
Dokument
908479
CareLit-ID
Jahr
2004
Publikation
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Metadaten
DOI
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Zusammenfassung
Background and Aims: Heme oxygenase-1 (HO-1) is the inducible isoform of the rate-limiting enzyme of heme degradation. Since overexpression of the HO-1 gene is protective against the deleterious effects of experimental injuries, the specific induction of HO-1 may have important clinical implications. So far it is not clear which cell type besides macrophages can contribute to HO-1 expression in normal, acutely or chronically damaged liver. Methods: Cryostat sections of normal or CCl4-damaged rat liver were investigated by immunohistochemistry using specific antibodies for rat HO-1, ED2, CD31, SM-a-actin and CK 8…
Schlagworte
CCl4
endothelial cells
heme oxygenase-1
liver fibrogenesis
Antibodies
Actin
Zeitschrift für Gastroenterologie
