CareLit Fachartikel
A silencer element in the first intron of the glutamine synthetase gene and its role in hepatocellular expression
F Gaunitz, K Heise, R Gebhardt · Zeitschrift für Gastroenterologie · 2004 · Heft 02
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908481
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Jahr
2004
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Zusammenfassung
The enzyme glutamine synthetase (GS) ranks as one of the most remarkable glucocorticoid-inducible mammalian genes. In many cells the synthetic glucocorticoid dexamethasone (Dex) increases GS expression severalfold. The response is mediated by a cellular glucocorticoid receptor (GR) that interacts with glucocorticoid responsive elements (GREs). In the rat gene it was demonstrated that two GREs are responsible for the effect observed in cell lines from lung and muscle, whereas the response to glucocorticoids in cell lines of hepatocellular origin is mediated by an element located in the first intron. Surprisingly,…
Schlagworte
GSSEr
enhancer
gene expression
glucocorticoid
glutamine synthetase
silencer
transcription
zonation
Dexamethasone
Zeitschrift für Gastroenterologie
