CareLit Fachartikel
Bile acid (BA) metabolism is impaired in mice with defective peroxisomal BA synthesis
C Münch, U Seedorf, M Fuchs · Zeitschrift für Gastroenterologie · 2004 · Heft 02
Dokument
908482
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Jahr
2004
Publikation
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Zusammenfassung
Impairment of peroxisomal BA synthesis is a characteristic feature of Scp2 (-/-) mice. This study investigated how this may impact BA metabolism. In separate groups of male mice (n=6–9) lipid analysis of hepatic and gallbladder bile was performed. Livers and sequential intestinal fractions were harvested to isolate total RNA, homogenate and plasma membranes. Steady-state gene expression of basolateral (Slc10a1, Slc21a1) and canalicular (Abcb4, Abcb11, Abcc2) transporters was studied and correlated with serum and biliary lipids. Size and composition of the BA pool was measured by GCMS and complemented with measur…
Schlagworte
bile acids
peroxisomes
sterol carrier protein 2
transporter expression
Alcohols
Chenodeoxycholic Acid
Cholesterol
Absorption
Cholate
Zeitschrift für Gastroenterologie
