CareLit Fachartikel

Gender Difference in the Pressor Response to Norepinephrine Reuptake Inhibition

C Schroeder, J Tank, S Härtter, FC Luft, J Jordan · Aktuelle Neurologie · 2004 · Heft 04

Dokument
908700
CareLit-ID
Jahr
2004
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Aktuelle Neurologie
Autor:innen
C Schroeder, J Tank, S Härtter, FC Luft, J Jordan
Ausgabe
Heft 04 / 2004
Seiten
–
Erschienen: 2004-04-06 00:00:00
ISSN
0302-4350
DOI
10.1055/s-2004-823162

Zusammenfassung

Background: Norepinephrine transporter (NET) dysfunction can contribute to the pathogenesis of orthostatic tachycardia. Orthostatic tachycardia predominantly affects women. This observation suggests gender differences in NET function. Methods: In a randomised, double-blind, crossover fashion 24 healthy subjects (12 men, aged 29±2yrs and 12 women, aged 29±2yrs) ingested 8 mg of the selective NET inhibitor reboxetine or placebo 12 hrs and 1 hr before testing. Finger blood pressure, brachial blood pressure, and heart rate were measured. After reaching a stable baseline in the supine position, we conducted a graded…

Schlagworte

Blood Pressure Blood Aged Observation After Aktuelle Neurologie