Development of a new electrochemical chip technology for gastrointestinal biopsy specimen cDNA analysis

Background: DNA microarray technology provides an efficient method for the detection of multiple gene polymorphisms at the same time. However, the combination of high number of measured polymorphisms necessary to reach statistical significance with today's high cost for a single measurements makes population-wide studies impossible. Aim: The goal of our project was to develop a new method to reduce time and cost of the DNA array measurements. Methods and results: The basis of a new array is a glass-slide sized alcali-free silicium dioxide slide. Here an Au coated chrome-dioxide base is fixed. Using photolythogra…