Long-term omeprazole and esomeprazole treatment does not significantly increase gastric epithelial cell proliferation and EGFR expression and has no effect on apoptosis and p53 ex…

Aims: Proton pump inhibitor (PPI) therapy is widely used in the treatment of patients with reflux oesophagitis. It is known that long-term omeprazole treatment reversibly increases gastric epithelial cell proliferation but there is limited information available about the in vivo changes of apoptosis, p53- and EGFR expression on gastric mucosa during long-term PPI treatment. Aims: To study the effect of long-term PPI therapy on gastric epithelial cell proliferation, apoptosis, p53- and EGFR expression. Methods: After informed consent, gastric biopsies of the antrum were taken from 14 and 12 patients with reflux e…