DNA flow cytometry and clinicopathology of intraepithelial neoplasms of the pancreas

Introduction: The purpose of this study was to analyze intraepithelial neoplasms of the pancreas, with particular attention to presentation, diagnostic workup, surgery, histopathology, and cytogenetics. We hypothesized that tumor ploidy pattern correlated with biological behavior, malignant potential and prognosis. Methods: The records of eight patients with pancreatic intraepithelial neoplasms were retrospectively reviewed. Nuclear DNA-content, ploidy, synthetic (S) phase and proliferative fractions of each neoplasm were measured by flow cytometry. Results: We report 4 cases of pancreatic ductal carcinomas in s…