Evaluation of immunohistochemical labelling and detection of intestinal mucin antigens in the gastric epithelium with and without intestinal metaplasia – Correlation to microscopi…

Background: Intestinal metaplasia (IM) is associated with the development of gastric carcinomas. Recently, immunhistochemical labelling techniques appeared to detect intestinal mucin products in routine gastric histological sections. The correlation between traditional microscopic, histochemical and the new immunhistochemical detection methods is not defined, yet. Methods: 5 um routine histological sections were prepared from 5o gastric biopsy specimen. The presence of intestinal metaplasia was determined by H/E, histochemical stainings. In additio SIMA and LIMA expression were investigated by semiquantitative i…