Effect of melatonin on the severity of L-arginine-induced experimental acute pancreatitis in rats
A Szabolcs, P Hegyi, G Pápai, I Varga, J Kaszaki, T Letoha, R Sári, J Lonovics, R Reiter · Zeitschrift für Gastroenterologie · 2004 · Heft 05
Bibliografische Angaben
Zusammenfassung
Free radicals and lipid peroxidation have an important role in the pathogenesis of the local and systemic inflammation during acute pancreatitis. The aim of this study was to determine the effect of the free-radical scavenger melatonin on the early phase of experimental acute necrotizing pancreatitis. Methods: Male Wistar rats were divided in five groups: A (3.2g/kg L-arginine (L-Arg) i.p. twice); MA (50mg/kg melatonin i.p. 30min prior to L-Arg); AM (50mg/kg melatonin i.p. 1h after L-Arg); M (50mg/kg melatonin i.p.); C (physiological saline i.p.). Rats were exsanguinated 24h after the last L-Arg injection. Resul…
