Redox homeostasis and element status of of the porphyria cutanea tarda patients with diabetes mellitus and alcoholism

Introduction: Porphyria cutanea tarda (PCT) is a disorder of heme biosynthesis resulting from a decreased activity of uroporphyrinogen decarboxylase (URO-D) enzyme. Other factors may contribute to the inhibition of URO-D: alcohol (alc), diabetes mellitus (DM), hepatitis C infection. The aim of this study was to evaluate the changes of redox-homeostasis and element status in PCT-, PCT-alc., and 2nd type DM, alc.,-PCT patients. Methods: 22 PCT male patients of Caucasian origin [10 PCT- (age: 61.60±12.93), 6 alc. PCT- (age: 56.66±5.27) and 6 DM, alc.,-PCT patients (age: 64.05±13.17)], and 6 healthy volunteers (age:…