Opposite changes of gastrointestinal motility in short- and long-term diabetic rats

The aim of the study was to establish whether a motility disturbance could be demonstrated in a rat model of type 1 diabetes and to investigate the correlation of motility dysfunction and diabetes duration and glycemic control. Materials and methods: Diabetes was induced in male adult rats by streptozotocin. Three groups of rats were investigated: diabetic, insulin treated diabetic and control group. In the treated group rats received 2U mixed insulin daily. Body weights and blood glucose levels were tested weekly. The duration of diabetes was 5 weeks for short-term diabetics (STD) and 10 weeks for long-term dia…