Successful liver transplantation in a patient with ulcerative colitis – Associated with primary sclerosing cholangitis, complicated by biliary sepsis

Introduction: Primary Sclerosing Cholangitis (PSC) is an idiopathic disorder, characterized by a progressive obliterative inflammatory fibrosis of the bile ducts. Case report: A 29-year-old male patient was diagnosed to have ulcerative colitis and PSC in 1995. On mesalazine (500mg t.i.d) and UDCA (250mg t.i.d) therapy he was symptom-free during the next 8 years, although his cholestatic liver enzymes increased gradually. Acute biliary pancreatitis manifested in April 2003. ERCP detected small stones in the common bile duct, many strictures and saccular dilatations of the intrahepatic bile ducts containing stones…