A PCR-based method allows the identification of any MLL translocation
C Meyer, B Schneider, S Wehner, M Reichel, S Angermüller, S Schnittger, C Schoch, MWJC Jansen, JJM van Dongen, R Pieters, OA Haas, S Strehl, T Dingermann, T Klingebiel, R Marschalek · Klinische Pädiatrie · 2004 · Heft 05
Bibliografische Angaben
Zusammenfassung
Acute leukemias are associated with specific chromosomal translocations of the human MLL gene. In general, MLL translocations define a distinct disease entity that needs to be diagnosed with precision to facilitate rapid clinical decisions. Here we present data about a PCR based method that uses patient genomic DNA to identify specific MLL fusions. Fourty different MLL translocations were successfully analyzed. We will present three novel MLL transloaction partner genes and will discuss the benefits of this novel technique for diagnosis and MRD analyses. Supported by grant 2001.061.1 from the Wilhelm Sander foun…
