CareLit Fachartikel
CUTL1–a modulator of tumor cell invasion and target of TGF-beta which is highly expressed in colon cancer
P Michl, M Ei'Bahrawy, R Poulsom, A Ramjaun, J Downward · Zeitschrift für Gastroenterologie · 2004 · Heft 08
Dokument
909097
CareLit-ID
Jahr
2004
Publikation
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Metadaten
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Zusammenfassung
CUTL1, also known as CDP/cux, is an evolutionary conserved homeodomain transcription factor which plays essential roles in development and cell cycle progression. However, little is known about the transcriptional targets of CUTL1 and its role in tumorigenesis and tumor progression. To elucidate the transcriptional program induced by CUTL1, we employed genome-wide expression profiling using Affymetrix microarrays comparing NIH3T3 cells with stable suppression of CUTL1 by shRNA technology and NIH3T3 cells with endogenous CUTL1 expression. These data revealed that CUTL1 activates a complex transcriptional program…
Schlagworte
CUTL1
TGF-beta
colon cancer
invasion
migration
transcription factor
Zeitschrift für Gastroenterologie
