Striatal Hypertrophy: A Mechanism for Preclinical Compensation in Parkin-Associated Parkinsonism?
F Binkofski, HR Siebner, C Buhmann, P Pramstaller, K Hedrich, T van Eimeren, C Büchel, C Klein, C Gaser · Klinische Neurophysiologie · 2004 · Heft 08
Bibliografische Angaben
Zusammenfassung
18F-Fluorodopa (F-DOPA) positron emission tomography (PET) demonstrated a reduction of striatal F-DOPA uptake in asymptomatic carriers of heterozygous Parkin mutations, indicating a latent dopaminergic dysfunction in the basal ganglia. We used voxel-based morphometry of high-resolution structural magnetic resonance images in a comparable group of asymptomatic Parkin mutation carriers to investigate whether this latent dopaminergic dysfunction is associated with structural abnormalities in the motor system. Structural MR data (T1-weighted FLASH 3D MR sequences; TE=5 ms; TR=15 ms; flip angle=30°; isotropic voxel s…
