Voxel MR Spectroscopy of Hippocampal Structures in Healthy Adults at 1.5 Tesla – How Stable are the Results?

Purpose: Although 1H-MRS is a non-invasive diagnostic tool for measuring metabolite alterations in patients with temporal lobe epilepsy, there are many sources of error, especially with regard to temporomesial structures. In order to meet the requirements of diagnostic tools, we evaluated the inter-subject variability and the test-retest stability of hippocampal single voxel 1H-MRS. Methods: We used an optimized, standardized method of short echo time 1H-MRS to study the hippocampal structures of 30 healthy adults. Spectral analysis and metabolite quantitation of N-acetylaspartate (tNAA), choline (Cho), creatine…