Zolmitriptan Reduces the Size of the Neurogenic Flare Reaction and the Primary Hyperalgesia after Electrical Stimulation

The triptan's mode of action (migraine medication) is not fully understood. Experimental data suggest a peripheral and a central pathomechanism. The aim of this study was the evaluation of zolmitriptan's (Z) impact on the peripheral neuropeptide release (neurogenic flare) and the primary and secondary hyperalgesia after electrical stimulation. Moreover, systematic differences between migraine patients and controls were examined. The study was performed in a double-blind, placebo-controlled and cross-over design. Ten migraine patients (8 female, 2 male; age 26.4±1.4 years) and 10 healthy controls (5 female, 5 mal…