In vivo Detection of the Neuropathological Hallmarks in Different Parkinsonian Syndromes by Voxel-Based Magnetization Transfer Imaging

Objective: To determine whether a whole brain voxel-by-voxel analysis of magnetization transfer imaging (MTI) using statistical parametric mapping (SPM) detects the known neuropathological changes in idiopathic Parkinson's disease (IPD), multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) in comparison to healthy controls. Background: Although much is known about the neuropathology of IPD, MSA and PSP from histological studies, the assessment of these changes in vivo remains difficult. MTI is an MRI technique which is more sensitive to neuropathological changes than conventional MRI and provid…