Effects of Interferon-beta-1-a therapy on cognition in multiple sclerosis

Cognitive deficits are common in multiple sclerosis (MS). They are only weakly associated with physical disability but substantially correlated with supratentorial lesion-load as well as with measures of general brain atrophy. This tudy was aimed to evaluate possible cognitive effects of IFN-beta-1a treatment in MS-patients over a 1-year-period. We studied a clinical population of altogether 10 MS-patients and also 10 education-matched healthy controls [Group CTRL]. The patient group consisted of 4 male and 6 female participants with a mean age of 36.7yrs and a mean EDSS-score of 3.3. Control subjects (5 male/5…