Conditional control of human wild-type and Parkinson's disease-associated mutant alpha-synuclein in transgenic mouse brain
S Nuber, T Schmidt, D Berg, M Neumann, C Holzmann, M Fendt, U Grasshoff, I Schmitt, A Bornemann, F Zimmermann, W Kuhn, SB Prusiner, M Bonin, A Servadio, O Riess · Aktuelle Neurologie · 2004 · Heft 09
Bibliografische Angaben
Zusammenfassung
The presynaptic protein alpha-synuclein has been implicated in the pathophysiology of many neurodegenerative disorders, including Parkinson's Disease and dementia with Lewy bodies, collectively referred to as synucleinopathies. To advance the study of the function of alpha-synuclein in these diseases, we have used the tTA-system to generate transgenic mice, which express human wildtype or mutated [A30P] alpha-synuclein in a conditional manner. To obtain reversible expression of human alpha-synuclein in the brain of these mice, we combined the tTA-system with both the PrP promotor and CaMKIIalpha promotor. We inv…
