Expression of T-cell activation markers in CSF of patients with neuroinflammatory diseases and controls

Introduction: Flowcytometry on cerebrospinal fluid (CSF) lymphocytes offers the opportunity to study immune regulation in the nervous system by assessing the expression of cell surface markers involved in T-cell activation. Early T-cell activation involves the expression of the IL-2 receptor subunit alpha (CD25), whereas HLA-DR and CD38 are late activation antigens. The purpose of this study was to analyse the expression of markers of early and late T-cell activation in CSF of patients with neuroborreliosis, viral meningomyeloradiculitis, multiple sclerosis (MS) and, as controls, noninflammatory neurological dis…