Monitoring of IL–2 Producing Cells After Liver Transplantation

T-cells play an important role during immunosuppression of patients after liver transplantation (LTX). We investigated the therapeutic effects during different transplantation periods on T-cells and their intracellular interleukin–2 (IL–2) production. Methods: 72 clinically stable LTX-patients under immunosuppressive therapy with Tacrolimus or cyclosporin A were monitored over a period of 12 months. The following groups were chosen: A: up to 1 year post-LTX (11 patients), B: 1–2 years post-LTX (15 patients) C: 2–5 years post-LTX (17 patients) D: more than 5 years post-LTX (29 patients); 19 healthy volunteers ser…