Relevance of Oncological Biomarkers for Differential Diagnosis in Lung Cancer

Aims: Because many oncological biomarkers lack tumor- and organ specificity, their usefulness for diagnosis of malignant diseases is still in discussion. However when biopsy of suspicious lesions can not be performed, the pattern of release or non-release of these markers might contain valuable information for differential diagnosis, particularly in lung cancer. Patients and Methods:. We investigated sera of 439 patients with non-operable lung cancer at time of diagnosis (311 NSCLC; among them 129 with squamous cell carcinoma, 89 with adenocarcinoma, and 93 with NSCLC without further specification; 113 of the NS…