The effect of mesalazin and prednisolone on indometacin provoked inflammation and changes of permeability in the intestinal tract

Aim of experiments: The aethiology of Crohn Disease (CD) despite intensive investigations remained unknown, therefore its therapy is unsolved. Chronic administration of non-steroidal anti-inflammatory drugs in humans or single administration of these drugs in experimental animals provoke ulcerative-inflammatory processes which are similar to CD. The change of the intestinal permeability may play a role in the aethiology of CD. Methods: In our experiments rats (Male Wistar rats weghing 250–300g) were treated by indometacin in a daily dose of 7.5, 10 and 16mg/kg subcutaneously (s.c.) for three days. One day after…