IL4 mediated suppression of autoimmunity in the central nervous system

Interleukin-4 (IL4) is a key cytokine that controls differentiation of T helper (Th) cells to Th2 effector cells and suppresses the development of Th1 cells. Autoimmunity in the central nervous system (CNS) is largely controled by Th1 effector cells. Objective: Here, we explore the potential of IL4 to suppress autoimmunity in the CNS using Experimental Autoimmune Encephalomyelitis (EAE), the animal model of Multiple Sclerosis (MS). Methods: EAE was induced as follows. Each mouse was injected s.c. on the back of the foot with a total of 50 nmol of the peptide myelin proteolipid protein AA139–151 (PLP139–151) in P…