CareLit Fachartikel

Glioma tropism of haematopoietic progenitor cells is mediated by CXCL12

G Tabatabai, O Bähr, J Wischhusen, I Eyüpoglu, J Rieger, M Weller, W Wick · Aktuelle Neurologie · 2005 · Heft 10

Dokument
910710
CareLit-ID
Jahr
2005
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Aktuelle Neurologie
Autor:innen
G Tabatabai, O Bähr, J Wischhusen, I Eyüpoglu, J Rieger, M Weller, W Wick
Ausgabe
Heft 10 / 2005
Seiten
–
Erschienen: 2005-10-26 00:00:00
ISSN
0302-4350
DOI
10.1055/s-2005-919652

Zusammenfassung

Adult stem and progenitor cells (PC) of various tissues are considered as promising candidates to establish a cell-based therapy against cancers, notably glioblastoma. Here we report that adult human and murine hematopoietic PC display a tropism for intracerebral experimental gliomas in vivo but not for normal brain tissue. Organotypic hippocampal slice culture and spheroid confrontation assays confirm a directed PC migration towards glioma cells ex vivo and in vitro. RNA interference-mediated disruption of transforming growth factor beta (TGF-Ò) synthesis by the glioma cells strongly inhibits PC cell migration.…

Schlagworte

Aktuelle Neurologie