Matrix metalloproteinase-inhibitor causes an activation of urokinase after experimental cerebral ischemia

Matrix metalloproteinases -2 and -9 (MMP-2/-9) are critically involved in the degradation of the basal lamina after experimental cerebral ischemia. Hemorrhages are closly related to microvascular basal lamina damage. The MMP activity is tightly regulated by exogenous and endogenous inhibitors. We investigated the effects of a synthetic inhibitor of MMP-2 and -9 (Calbiochemâ No. 444241) on the damage of the basal membrane, the occurred cerebral hemorrhages and the interference with the plasminogen/plasmin system. Experimental cerebral ischemia in rats was induced for 3h and followed by 24h reperfusion (suture mod…