The Number of Lymph Node Metastases in Gastric Cancer correlates with the Angiotensin II-receptor 1 (AT1R)
C Röcken, E Diebler, S Carl-McGrath, U Lendeckel, P Malfertheiner, A Roessner, M Ebert · Zeitschrift für Gastroenterologie · 2006 · Heft 04
Bibliografische Angaben
Zusammenfassung
Purpose: In the present study, we aimed to substantiate the putative significance of angiotensin II receptors type 1 (AT1R) and type 2 (AT2R) on gastric cancer biology. Materials and Methods: Local expression of AT1R and AT2R was investigated by immunohistochemistry in 82 gastric cancer patients operated on between 1995 and 2002 who had undergone either complete or partial gastrectomies. Tissue samples were fixed in 10% neutralized formalin and embedded in paraffin. Deparaffinized sections were stained using hematoxylin and eosin. The TNM stage was determined according to the UICC guidelines. Immunostaining was…