Analysis and validation of differential gene expression in serous ovarian tumors of varying grade and malignant potential

Topic: Gene expression profiling is increasingly used to evaluate the molecular properties of ovarian cancer, including distinctions between carcinomas of differing histology, tumor progression and prognosis. Little is known about the molecular differences among lesions of low malignant potential (LMP) and invasive carcinomas of varying grade. Furthermore, it is still impossible to detect early stages of disease. Novel blood serum markers may be suitable to fill this gap. Methods: We used oligonucleotide arrays to profile the expression of 12500 genes in a series of 52 serous ovarian tumors, including 8 LMP tumo…