Other cancer types besides breast and ovarian cancer in 266 families with a proven BRCA1/2 mutation or a high probability for an autosomal dominant gene

Objective: BRCA1/2 mutations go along with a significantly elevated lifetime risk for breast and ovarian cancer reaching up to 80% and 50% respectively. Both genes are supposed to participate in a common pathway that is involved in the control of DNA damage repair. This fundamental role rises the question whether mutations in these genes predispose towards cancerous lesions in other tissues. Patients: Our data were collected in a prospective study of women participating in a screening programme supported by the German Cancer Aid. We report on 2982 family members of 266 high risk families for breast and ovarian c…