CareLit Fachartikel
The Endocannabinoid Anandamide Selectively Induces Cell Death in Hepatoma Cell Lines
SV Siegmund, DA Brenner, RF Schwabe · Zeitschrift für Gastroenterologie · 2006 · Heft 01
Dokument
911525
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Jahr
2006
Publikation
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Zusammenfassung
Background: Endocannabinoids mediate antineoplastic effects in several cancers including breast and prostate cancer. We have shown that the endocannabinoid anandamide (AEA) does not induce cell death in primary hepatocytes due to high expression of the AEA-degrading enzyme fatty acid amide hydrolase (FAAH). Aim: To determine whether the endocannabinoid AEA induces growth arrest and cell death in hepatoma cell lines. Methods: Rat and human hepatoma cell lines (FaO, McA-RH7777, HepG2, Hep3B, PCL/PRF/5) and primary rat hepatocytes were treated with varying concentrations of AEA. Cell death was determined by LDH rel…
Schlagworte
Anandamide
Anti-cancer Therapy
Cell death
Endocannabinoids
Hepatocytes
Hepatoma
Zeitschrift für Gastroenterologie
