The spectrum of oxaliplatin-induced hyperexcitability of the peripheral nerves

Background: Oxaliplatin, displays frequent acute neurotoxicity. Hyperexcitability of the peripheral nerves induces transient disabeling sensory and motor symptoms attributed to a still undefined channelopathy. The study was performed to assess the incidence and spectrum of the clinical and electrophysiologic abnormalities. Methods: 20 patients received oxaliplatin as part of their anticancer therapy. Investigations were performed 24 hours and 14 days after oxaliplatin, the latter just before the next cycle. Clinical symptoms were assessed by a standardized questionnaire. Electrophysiologic investigations include…